Funding Opportunity Number: CDC-RFA-CE-26-0110
Agency: U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC)
Assistance Listing: 93.799 — CARA Act – Comprehensive Addiction and Recovery Act of 2016
Funding Instrument: Grant
Category: Health
Estimated Total Funding: $16,875,000
Award Ceiling: $75,000 per project
Expected Number of Awards: 45
Cost Sharing: Not required
Application Deadline: January 21, 2026 (at 11:59 PM ET)
Posted: September 30, 2025 | Archive Date: February 20, 2026
The Comprehensive Addiction and Recovery Act (CARA) Community-Based Coalition Enhancement Grant Program funds efforts to prevent and reduce youth opioid and methamphetamine use and the misuse of prescription drugs among youth ages 12–18 across the United States. Administered through the CDC in partnership with the Office of National Drug Control Policy (ONDCP), the program builds on the Drug-Free Communities (DFC) Support Program by providing additional resources to current or former DFC grantees.
Eligible applicants are community-based coalitions addressing local drug crises that are either current or former DFC Support Program recipients. They must be nonprofit entities (as defined under 501(c)) or other qualified domestic organizations such as state and local governments, federally recognized tribes, state-recognized tribes, urban Indian organizations, colleges and universities, professional associations, faith-based and voluntary organizations, and community coalitions. Applicants must document that their community’s rates of opioid or methamphetamine misuse exceed the national average over a sustained period.
The program’s purpose is to enhance coalition capacity to address local substance use problems through youth-focused prevention strategies, community engagement, and cross-sector collaboration. Funds may be used for planning, training, data collection, community education, and evidence-based interventions that reduce drug availability and youth risk factors.
Awards will average up to $75,000 per recipient for the grant period. There is no matching requirement. All activities must take place within the United States or U.S. territories.
